Donald Weaver
University of Toronto |
Dr. Weaver's research interests are focused on computer-aided drug design and medicinal chemistry with particular applications to chronic neurodegenerative disorders such as Alzheimer's disease (AD), protein misfolding dementia (tauopathies), epilepsy and stroke. His general approach employs a variety of theoretical chemistry techniques (ab initio calculations and density functional theory through molecular dynamics) to design small molecules capable of binding to designated receptor sites. The molecules are then synthesized using synthetic organic chemistry methods and evaluated in an iterative process of compound optimization driven by quantitative structure-activity relationship calculations.
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